Sean Serino is a Los Angeles writer, actor, director and producer. Originally from New Orleans, she studied at the New Orleans Center for Creative Arts before receiving a bachelor’s degree in Theatre from Northwestern University in Evanston, Illinois. At Northwestern, she was mentored by chamber theatre visionary and MacArthur Fellow Mary Zimmerman, appearing in Zimmerman's Ovid adaptation Six Myths.  

Her film roles include Jerry Bruckheimer's Glory Road and the independent drama At Last. She starred in The Rage and The Dead Matter, produced by KNB co-founder and special effects veteran Robert Kurtzman and distributed by Sam Raimi's Ghost House Pictures. 

Her semi-autobiographical play, Rue Royale, premiered at the 2012 Hollywood Fringe Festival. In 2019, she received a Gilchrist Foundation grant to direct an updated version of Rue Royale at Morningside College in Sioux City, Iowa as part of their American Playwright Series. Current projects include the recently-produced pilot of her original comedy digital series, Meddlesome, and screenplays for Familial, a psychological horror feature and The Scarlet, a one-hour TV pilot.